Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats

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Nimodipine decreases the minimum alveolar concentration of isoflurane in dogs.

Nimodipine is a calcium antagonist that binds with high affinity to neuronal membranes. It is a potent cerebrovasodilator and has been demonstrated also to affect neurotransmitter synthesis and release. Because patients undergoing surgery for intracranial aneurysms are frequently receiving nimodipine, the authors determined the MAC of isoflurane in six dogs before and during three infusion dose...

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Effects of fentanyl on isoflurane minimum alveolar concentration and cardiovascular function in mechanically ventilated goats.

The effects of fentanyl on the minimum alveolar concentration (MAC) of isoflurane and cardiovascular function in mechanically ventilated goats were evaluated using six healthy goats (three does and three wethers). Following induction of general anaesthesia with isoflurane delivered via a mask, endotracheal intubation was performed and anaesthesia was maintained with isoflurane. The baseline MAC...

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Effects of propofol on isoflurane minimum alveolar concentration and cardiovascular function in mechanically ventilated goats.

OBJECTIVE To evaluate the effects of propofol, on isoflurane minimum alveolar concentration (MAC) and cardiovascular function in mechanically ventilated goats. STUDY DESIGN Prospective, randomized, crossover experimental study. ANIMALS Six goats, three does and three wethers. METHODS General anaesthesia was induced with isoflurane in oxygen. Following endotracheal intubation, anaesthesia ...

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The effects of i.v. fentanyl administration on the minimum alveolar concentration of isoflurane in horses.

BACKGROUND Fentanyl decreases the minimum alveolar concentration (MAC) of inhaled anaesthetics and has been used clinically to reduce the requirements of other anaesthetic drugs in humans and small animals. We hypothesized that i.v. fentanyl would decrease the MAC of isoflurane in horses in a dose-dependent manner. METHODS Following determination of baseline MAC of isoflurane, fentanyl was ad...

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It has been suggested previously that tramadol increases central nervous system activity and 'lightens' anaesthesia with volatile agents. We assessed the effects of tramadol on the minimum alveolar concentration (MAC) of isoflurane in 56 Wistar rats, instrumented chronically with an arterial and central venous catheter. The MAC of isoflurane was determined using the tail clamp method under thre...

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ژورنال

عنوان ژورنال: Journal of Veterinary Pharmacology and Therapeutics

سال: 2020

ISSN: 0140-7783,1365-2885

DOI: 10.1111/jvp.12886